The OPALS many hats

Two hats too many

We view ourselves as scientists as very intelligent, extremely hard-working, and highly creative, though perhaps more competitive than we care to admit. But no one seems to recognize the high incidence of a serious medical problem among investigators — 'multiple personality disorder'. Of course I say this with tongue planted firmly in cheek, but it's not too far off the mark when we consider ou...

177-2009: The Many Hats of the SAS® Administrator

The SAS administrator exists in all types of organizations: small, medium, large, etc. This paper focuses on medium-to-large scale SAS ® System implementations. The SAS Administrator is not a position as much as it is a role. It can be a single individual or a team comprised of SAS-trained personnel, along with other IT staff within a company. While this role is very important, it is often not ...

Yoda and the fountain of youth? The many hats of IGF-1

The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease

Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it also contributes to neuronal differentiation, axonal pathfinding and synapse formation and function. To participate in these diverse events, Sh...

Many hats: intratrial and reward level-dependent BOLD activity in the striatum and premotor cortex.

Human functional magnetic resonance imaging (fMRI) studies, as well as lesion, drug, and single-cell recording studies in animals, suggest that the striatum plays a key role in associating sensory events with rewarding actions, both by facilitating reward processing and prediction (i.e., reinforcement learning) and by biasing and later updating action selection. Previous human neuroimaging rese...